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Prenatal Folic Acid and Schizophrenia Prevention

Joshua Roffman, MD, MMSc, is the director of research in the Schizophrenia Clinical and Research Program and the co-director of Mass General Neuroscience. His recent research leveraged the folic acid fortification of the American grain supply in the mid-1990s as a natural experiment to study its effect on brain development. They found that folic acid exposure in utero was associated with brain changes that appear to be protective against risk for schizophrenia.

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7 thoughts on “Prenatal Folic Acid and Schizophrenia Prevention

  1. The approach described here is overlooking an enormous detail: the inability of those with certain MTHFR mutations to convert folic acid into methylfolate. Folic acid is toxic for those of us with the C677T variation. Everyone needs methylfolate but folic acid is not the answer for those of us with methylation issues.

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