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Does Intermittent Fasting Increase Human Life Expectancy?



Alternate-day modified fasting is put to the test for lifespan extension.

Get the preface for Dr. Greger’s brand-new book, How Not to Diet, by subscribing to his free newsletter at

Well that was interesting! I had never even heard of that study until I started digging into the topic.

There are a few more videos coming up in this fasting series. Stay tuned for:
• The 5:2 Diet and the Fasting-Mimicking Diet Put to the Test (
• Time-Restricted Eating Put to the Test (
• The Benefits of Early Time-Restricted Eating (

Here are all of the previous ones if you missed any:
• The 3,500 Calorie per Pound Rule Is Wrong (
• The Reason Weight Loss Plateaus When You Diet (
• The New Calories per Pound of Weight Loss Rule? (
• The Benefits of Calorie Restriction for Longevity (
• Potential Pitfalls of Calorie Restriction (
• Benefits of Fasting for Weight Loss Put to the Test (
• Is Fasting Beneficial for Weight Loss? (
• Is Fasting for Weight Loss Safe? (
• Alternate-Day Intermittent Fasting Put to the Test (
• Is Alternate-Day Intermittent Fasting Safe? (

For more on longevity, check out:
• Increased Lifespan from Beans (
• Fruits, Veggies, and Longevity: How Many Minutes Per Mouthful? (
• The Okinawa Diet: Living to 100 (
• Methionine Restriction as a Life-Extension Strategy (

Have a question about this video? Leave it in the comment section at and someone on the NutritionFacts.org team will try to answer it.

Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics.

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Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM

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37 thoughts on “Does Intermittent Fasting Increase Human Life Expectancy?

  1. i swear this dude is one of the smartest people on the planet
    almost done with his "how not to die" audiobook
    the daily dozen is fantastic
    its life changing
    i love you greger
    keep shining your light 🙂

  2. As usual, real science and research disagrees with “Dr.” Gregor.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454488/#!po=69.3182

  3. I was over weight with diabetes and my intestines were literally rotting (chronic diverticulitis). I had a fatty cirrhotic liver. I felt like dying everyday. I started fasting for 24 hrs every other day. I started taking milk thistle, marshmallow root and a 20billion 9 strain probiotic everyday. I eat what I want when I want on my non fasting days. NOTE: by nature your body starts rejecting crappy food and leans towards richer proteins and good fats like avocados. No longer diabetic, no longer cirrhotic, no more diverticulitis flare ups and normal weight…..

  4. Thought one of the main points of your book was about keeping as active as possible so that you can eat as much calories whole plant foods to flood your body with antioxidants. Seems if you calorie restrict or fast than goes completely against this.

  5. This topic will be restricted / squashed just and treated with careful "tobacco science" by big food and big medicine…. and less healthy things like the meat and cheese KETO diet promoted …. More death and disease = more profit ..

  6. Dr. Greger, you should make a playlist for convincing people to change their diet! Something I can send people a link to when they ask why I'm vegan

  7. The title of the study is literally “alternate day *calorie restriction*”. Why call it “alternate day fasting” ?
    Again, *not* the same thing.

  8. Starving then binging is not good for health or emotional state. Best to be in a routine of eating very basic same old food. If you start playing games with smoothies, nuts or nut butters, vegan desserts/confections, or sweet fruits, you can easily get into a craving binging scenario. Plain old whole starchy staples and vegetables is the best way with modest fruit.

  9. Is it possible that the experimental group ate more fruits since that was one of 2 food groups they could eat on fasting days, and that this lead to a better result?
    Or that they had better results because they consumed more milk?

  10. Dear Dr. Gregor,

    I have a very important question to ask and would be extremely happy about any form of reply!
    I recently did a complete DNA/microbiome test, where they tested my gut bacteria and other gut markers.

    My markers generally speaking pretty good. They found out that my microbiome is dominated by the "Ruminococcus" bacteria. However, it turned out that I am laking some bacteria that I find to be pretty crucial. They categorized by vitamin producing (we are talking about b12 and K) bacteria, which seem to be close to non-existent, or even non-existent in my gut. Regarding B12 it is Propionibacterium, Bacillus, and Lactobacillus that all mark 0.0. Looking at Vitamin K it is Enterobacter, Lactococcus, and Serratia with 0.0.

    My question is: Are the bacteria essential to build the vitamin. I know B12 is build by bacteria. So what if there is a lack of the bacteria producing B12. Can you counteract it with supplementation? I could send the report too, it's in German though. 😀

    I have been plant-based for about 5 years now, 24 years old, 183cm (6"0) and about 93kg. I do strength training so I would say I am overweight, but a body fat percentage of 18% could be true, Christmas is approaching…

  11. Disappointed to see ZDoggMD talk about Vegan nutrition and “bad science” in his video on YouTube,
    Sure wish Dr. Greger could set him straight. Would love to see a rebuttal or even better an appearance on his talk show.

    https://youtu.be/ORZ2md-YyZY

  12. so, I still feel confused about this. I'm on my 30s but want to know if I can go for this to keep my weight in the line since I love eating a high starchy diet. Thanks!

  13. Why talk about a study with COI and waste our time? Also 900 calories of sugar isn't fasting. You should know that…

  14. Please look at intermittent fasting like 16/8 or 20/4 or even 23/1 without alternate day cycles. Haven't heard you mention autophagy once, which is like the main benefit of fasting isn't it?

  15. This trial doesn't seem unethical to try again. Just some people who want to calorie restrict half the time

  16. Asthma is an inflammatory disease. Most of my inflammation responses are from food…wheat and dairy milk being the top two. It look me until my early 40's to realize this…so, for anyone with asthma, eat plants only, then deal with the animal hair, grass, molds, smoke, fragrances, or anything else you would take an antihistamine for. The biggest culprit is the food we eat. My allergies and asthma now is almost non existent, and I really wish I knew this sooner.

  17. can you intermittant fasting where you just eat one meal a day. an apple, an ornage and a bannana is all i eat during this one meal

  18. Have you ever checked into this story about a man who at age 27 over 350 pounds fasted for over a year on coffee, tea and water? It was supposedly documented by medical doctors it would be interesting to hear your thoughts on this. Here's a link in case you haven't heard of it before; Watch "A Man Who Refused to Eat for 382 Days and Lost 275 Pounds" on YouTube
    https://youtu.be/xJAL5eUBpIQ

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